Moderate ResearchLongevityImmune

Vilon

KE Dipeptide | Thymus Immune Bioregulator

Half-life

Not established

Chain length

2 amino acids

Reference frequency

Daily for 10-20 consecutive days (Khavinson bioregulator cycle)

Research overview

DoseGear research brief

Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it acts as a molecular signaling compound that restores normal gene expression and protein synthesis in immune and epithelial cells. Research shows Vilon increases mean lifespan by 20-40% in animal studies and suppresses tumor development.

Mechanism of action

Vilon works through epigenetic modulation, restoring chromatin structure and gene expression in immune cells. It stimulates thymocyte proliferation, activates T-helper cells, and increases the proliferative index in thymus tissue (from 26% to 37% in studies). The peptide modulates tyrosine phosphorylation of mitogen-activated cytoplasmic kinases and helps rejuvenate aged immune systems by restoring proper gene expression patterns.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Synthetic Lys–Glu dipeptide associated with thymic and Khavinson research.

What it is researched for

Immune-cell and aging-model research involving proposed chromatin, gene-expression, and immune-regulatory effects.

Research observation window

Not reported in the reviewed compound-specific evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research context	Amount	Frequency	Route
Cycle 1 Day 1 reference	67 mcg	See source guide · See source guide	Injectable · 20 mg lyophilized vial + 3 mL BAC Water

Reference cycle

10-20 day cycle (typical 10 days in research)

Reference storage

Lyophilized powder/reconstituted: 2-8°C refrigerated

Safety context

Reported side effects

Generally well-tolerated
Minimal side effects reported

Contraindications & cautions

Active autoimmune flares (consult physician)
Known hypersensitivity
Pregnancy or breastfeeding

Scientific references

01
Peptide Bioregulators Increase Lifespan
Scientific citationPeptide Bioregulators Increase Lifespan. Biogerontology (2003).
02
Vilon Effects on Aged Lymphocytes
Scientific citationVilon Effects on Aged Lymphocytes. Bulletin of Experimental Biology and Medicine (2002).
03
Peptides Regulating Proliferative Activity in THP-1 Cells
Scientific citationPeptides Regulating Proliferative Activity in THP-1 Cells. PMC (2022).
04
Short Peptide Immunoprotecting Properties
Scientific citationShort Peptide Immunoprotecting Properties. Advances in Gerontology (2018).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

Related research profiles

Longevity