PreclinicalLongevityMetabolic

5-Amino-1MQ

NNMT Inhibitor | Longevity & Metabolic Enhancement

Half-life

4-7 hours (3.8h IV)

Chain length

Not applicable

Reference frequency

Once daily, preferably morning

Research overview

DoseGear research brief

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.

Mechanism of action

Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Synthetic methylquinolinium small molecule studied by Neelakantan and colleagues; it is not a peptide.

What it is researched for

Obesity and adipocyte metabolism in preclinical models through NNMT inhibition and altered nicotinamide methylation.

Research observation window

An 11-day subcutaneous mouse experiment assessed weight and adipose outcomes. No established human response window is reported.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research context	Amount	Frequency	Route
Initial tolerance	2.5 mg	Once daily · Days 1–2	Injectable · 5 mg lyophilized vial + 1 mL BAC Water
Standard reference	5 mg	Once daily · Days 3+	Injectable · 5 mg lyophilized vial + 1 mL BAC Water
Alternative split reference	2.5 mg	Twice daily · Days 3+	Injectable · 5 mg lyophilized vial + 1 mL BAC Water

Reference cycle

8-12 weeks continuous

Reference storage

Injectable: lyophilized room temp or freezer, reconstituted 2-8°C for 28 days

Safety context

Reported side effects

Generally minimal side effects
Occasional mild GI adjustment
Potential sleep interference if dosed late in day

Contraindications & cautions

Pregnancy or breastfeeding
Pre-existing metabolic conditions (consult healthcare provider)

Scientific references

01
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Scientific citationSelective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology (2018).
02
Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice
Scientific citationNicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Scientific Reports (2024).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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