Well StudiedCognitiveLongevity

Selank

Anxiolytic & Nootropic Peptide | Tuftsin Analog

Half-life

2-10 minutes

Chain length

7 amino acids

Reference frequency

1-2x daily (morning and/or evening)

Research overview

DoseGear research brief

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.

Mechanism of action

Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Synthetic tuftsin-related peptide developed in Russian research.

What it is researched for

Anxiety and neurotransmission research involving GABAergic gene expression and other neurotransmitter effects.

Research observation window

A rat gene-expression study assessed one hour; the source reports human anxiety effects persisting up to one week after administration.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research context	Amount	Frequency	Route
Mild anxiety relief	250mcg	1x daily	SubQ
Moderate anxiety/cognitive	250mcg	2x daily (morning & evening)	SubQ
Intensive anxiety support	500mcg	1x daily (divided doses)	SubQ
Cognitive enhancement	250-350mcg	1x daily (morning)	SubQ
PTSD support	250mcg	2x daily	SubQ
Immune support	250mcg	1x daily for 2-4 weeks	SubQ

Reference cycle

2-8 weeks on

Reference storage

Reconstituted: 2-8°C, use within 30 days

Safety context

Reported side effects

Minimal side effects - excellent safety profile
No sedation or cognitive impairment
No tolerance, dependence, or withdrawal

Contraindications & cautions

Known peptide allergies
Pregnancy or breastfeeding
Consult healthcare provider with multiple psychiatric medications

Scientific references

01
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
Scientific citationSelank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology (2016).
02
Efficacy and Possible Mechanisms of Action of a New Peptide Anxiolytic Selank in the Therapy of Generalized Anxiety Disorders and Neurasthenia
Scientific citationEfficacy and Possible Mechanisms of Action of a New Peptide Anxiolytic Selank in the Therapy of Generalized Anxiety Disorders and Neurasthenia. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova (2008).
03
Intranasal Administration of the Peptide Selank Regulates BDNF Expression in the Rat Hippocampus In Vivo
Scientific citationIntranasal Administration of the Peptide Selank Regulates BDNF Expression in the Rat Hippocampus In Vivo. Doklady Biological Sciences (2008).
04
Experimental Optimization of Learning and Memory Processes by Selank
Scientific citationExperimental Optimization of Learning and Memory Processes by Selank. Eksperimental'naia i Klinicheskaia Farmakologiia (2010).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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