DG Peptide Protocols
Moderate ResearchCognitiveLongevity

NA-Selank Amidate

N-Acetyl Selank Amidate

N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic

Half-life
4-6 hours
Chain length
7 amino acids (acetylated, amidated)
Reference frequency
1-2x daily for 14-20 days

Research overview

DoseGear research brief

NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding. Unlike benzodiazepines, it provides anxiety relief without sedation, dependency, or cognitive impairment.

Mechanism of action

NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines. The peptide activates serotonin metabolism in the hypothalamus and brainstem, and increases BDNF levels to promote neuronal growth and differentiation.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Acetylated and amidated Selank derivative.

What it is researched for

Proposed anxiolytic and cognitive research based on Selank-like neurotransmission; derivative-specific validation is limited.

Research observation window

Not reported for this derivative; cited 14-day studies concern Selank.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

No sourced lyophilized-vial injectable protocol is listed for this profile.

Safety context

Reported side effects

  • Generally well-tolerated
  • Mild nasal irritation (intranasal)
  • Fatigue (rare)

Contraindications & cautions

  • Pregnancy or breastfeeding
  • Known hypersensitivity to Selank or tuftsin
  • Severe psychiatric conditions (consult professional)

Scientific references

  1. 01

    Selank Administration Affects Expression of Genes in GABAergic Neurotransmission

    Scientific citationSelank Administration Affects Expression of Genes in GABAergic Neurotransmission. Frontiers in Pharmacology (2016).
  2. 02

    Selank Clinical Trial in Anxiety Disorders

    Scientific citationSelank Clinical Trial in Anxiety Disorders. Zhurnal Nevrologii i Psikhiatrii (2008).
  3. 03

    Selank and Serotonin Metabolism

    Scientific citationSelank and Serotonin Metabolism. Bulletin of Experimental Biology and Medicine (2006).
  4. 04

    Selank and BDNF Expression

    Scientific citationSelank and BDNF Expression. Regulatory Peptides (2009).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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