Mitochondrial Open Reading Frame of the 12S rRNA-c
Mitochondrial-Derived Peptide | Metabolic Regulator
DoseGear research brief
MOTS-c is a mitochondrial-derived peptide that operates as a mitohormone through the Folate-AICAR-AMPK pathway. Under metabolic stress, it translocates to the nucleus to bind stress-response transcription factors (NRF2, ATF1/ATF7), regulating genes involved in metabolism and cellular adaptation.
Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation.
Compound background
Study windows describe what researchers measured, not when an individual should expect a result.
Mitochondrial-DNA-associated peptide.
Metabolic stress, insulin sensitivity, and aging research involving AMPK-associated signaling and stress-dependent nuclear actions.
Cell research observed nuclear translocation within 30 minutes under metabolic stress; this is not an injected-treatment response timeline.
Reference data
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Metabolic health | 5-10mg | Once daily | SubQ |
| Anti-aging protocol | 15mg | 3x weekly | SubQ |
| Exercise performance | 10-15mg | Pre-workout | SubQ |
| Conservative start | 5mg | Once daily | SubQ |
Reference cycle
4-12 weeks depending on goals
Reference storage
Refrigerate reconstituted solution at 2-8°C, use within 14 days
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
MOTS-c Increases in Skeletal Muscle Following Long-Term Physical Activity and Improves Acute Exercise Performance After a Single Dose
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.
