DoseGear research brief
Kisspeptin acts as a master regulator of the reproductive system, stimulating GnRH neurons essential for puberty, fertility, and reproductive function.
DG Peptide Protocols
EmergingSexual Health
Kisspeptin
KP-10
KISS1 Gene Product | Reproductive Neuropeptide
Research overview
Mechanism of action
Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release, which stimulates pituitary LH/FSH secretion and gonadal steroid production.
Compound background
Development & research timeline
Study windows describe what researchers measured, not when an individual should expect a result.
Origin & development
Endogenous KISS1-derived peptide family.
What it is researched for
Reproductive-axis, fertility, and sexual-response research through KISS1R activation and hypothalamic GnRH signaling.
Research observation window
Not reported in the reviewed compound-specific evidence. Formulation stability is not an effects timeline.
Reference data
Lyophilized vial injectable protocols
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Gonadotropin stimulation | 100-200mcg | Single dose or 2-3x weekly | SubQ |
| Fertility support | 0.4-1.0 nmol/kg (50-150mcg) | As directed by physician | SubQ (KP-54) |
| Sexual function (clinical) | 1 nmol/kg/h | 75-minute IV infusion | IV infusion |
Reference cycle
2-4 weeks
Reference storage
Lyophilized: Room temperature; Reconstituted: 2-8°C; KP-10: use within 7 days; KP-54: use within 14 days
Safety context
Reported side effects
- Minimal acute side effects reported
- Potential mild cardiovascular effects
Contraindications & cautions
- Not recommended during pregnancy or breastfeeding
- Caution with cardiovascular disease history
- Daily dosing causes receptor desensitization
Scientific references
- 01
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial
Scientific citationEffects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open (2023). - 02
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial
Scientific citationEffects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open (2022). - 03
Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of OHSS During IVF Therapy
Scientific citationEfficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of OHSS During IVF Therapy. Journal of Clinical Endocrinology & Metabolism (2015). - 04
Intranasal Kisspeptin Administration Rapidly Stimulates Gonadotropin Release in Humans
Scientific citationIntranasal Kisspeptin Administration Rapidly Stimulates Gonadotropin Release in Humans. eBioMedicine (2025).
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.