GnRH
Gonadotropin-Releasing Hormone | GnRH Agonist
DoseGear research brief
Gonadorelin is a synthetic form of the naturally occurring gonadotropin-releasing hormone (GnRH). It stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn regulate testosterone production in men and ovulation in women. It is FDA-approved for diagnostic testing and fertility treatment. The pulsatile nature of GnRH secretion is critical for proper reproductive function.
Gonadorelin acts as an agonist of the GnRH receptor in the anterior pituitary. When administered in pulses (mimicking natural secretion patterns every 60-120 minutes), it stimulates release of FSH and LH. LH then stimulates Leydig cells in the testes to produce testosterone, or triggers ovulation in women. Continuous exposure paradoxically causes receptor downregulation and suppressed hormone production.
Compound background
Study windows describe what researchers measured, not when an individual should expect a result.
Synthetic version of endogenous gonadotropin-releasing hormone.
Pituitary testing and reproductive-endocrine research through GnRH-receptor activation and LH/FSH release.
Not reported in the reviewed compound-specific evidence.
Reference data
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Diagnostic testing | 100 mcg | Single injection | SubQ or IV |
| Fertility support | 50-100 mcg | 2-3x weekly | SubQ |
| Pulsatile therapy | 5-20 mcg per pulse | Every 90-120 min | SubQ pump |
| TRT adjunct | 100-200 mcg | 2-3x weekly | SubQ |
Reference cycle
Varies - diagnostic single use, fertility therapy ongoing, TRT support continuous
Reference storage
Lyophilized: 2-8°C refrigerated; Reconstituted: 2-8°C refrigerated, use within 14 days due to short stability
Gonadorelin in Hypogonadotropic Hypogonadism
GnRH Pulsatility and Reproductive Function
Gonadorelin for Ovulation Induction
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.
