DG Peptide Protocols
Well StudiedLongevityImmune

Epitalon

Epithalon

Synthetic Pineal Tetrapeptide | Telomerase Activator

Half-life
Not established (short peptide)
Chain length
4 amino acids
Reference frequency
Once daily for 10-20 consecutive days

Research overview

DoseGear research brief

Epitalon is a synthetic tetrapeptide developed by Russian scientist Vladimir Khavinson with 35+ years of research. It activates telomerase at extremely low concentrations to maintain telomere length, stimulates melatonin production, and modulates gene expression through epigenetic mechanisms.

Mechanism of action

Activates telomerase at extremely low concentrations (10⁻¹⁷ to 10⁻¹⁵ M) to maintain telomere length, stimulates melatonin production from the pineal gland, and modulates gene expression through epigenetic mechanisms.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Synthetic tetrapeptide developed in Khavinson-associated pineal research.

What it is researched for

Telomerase, circadian biology, and aging models through proposed gene-regulatory and neuroendocrine effects.

Research observation window

A mouse study administered injections from three months of age until natural death. A cited 6–8-year human study used Epithalamin, not Epitalon.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research contextAmountFrequencyRoute
Standard anti-aging200-500mcg1x daily for 10-20 daysSubQ
Conservative start100mcg1x daily for 10-20 daysSubQ
Russian clinical equivalent300mcg1x daily for 10-20 daysSubQ
Ultra-low dose50mcg1x daily for 10-20 daysSubQ

Reference cycle

10-20 days per cycle

Reference storage

Lyophilized: 2-8°C refrigerated; Reconstituted: 2-8°C refrigerated, use within 30 days

Safety context

Reported side effects

  • Generally well-tolerated with minimal side effects
  • Mild injection site reactions
  • Vivid dreams (melatonin-related)

Contraindications & cautions

  • Active malignancy (telomerase activation concern)
  • Chronic sinusitis (nasal route)
  • Known peptide allergies
  • Pregnancy or breastfeeding

Scientific references

  1. 01

    Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

    Scientific citationEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine (2003).
  2. 02

    Peptides of pineal gland and thymus prolong human life

    Scientific citationPeptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters (2003).
  3. 03

    Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys

    Scientific citationSynthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuroendocrinology Letters (2001).
  4. 04

    Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa

    Scientific citationPineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuroendocrinology Letters (2002).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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