Moderate ResearchLongevityImmune

Crystagen

EDP

EDP Tripeptide | Thymus Immune Bioregulator

Half-life

Minutes (short peptide); effects persist via epigenetic changes

Chain length

3 amino acids

Reference frequency

Once daily for 10-20 consecutive days

Research overview

DoseGear research brief

Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it enhances immune function by stimulating normal lymphocyte proliferation while inhibiting tumor cell growth. Research shows effectiveness in normalizing immunity in 82% of elderly patients (vs 56% control) and reducing respiratory infections in athletes by doubling HSP gene expression.

Mechanism of action

Crystagen works through epigenetic regulation by influencing gene expression and protein synthesis in immune cells. It regulates the synthesis of heat-shock proteins, cytokines, and affects cell differentiation, proliferation, and apoptosis. The EDP peptide enhances spontaneous proliferative activity of normal lymphocytes while inhibiting proliferation of tumor cells (K-562 erythromyelosis). It activates B-cell immune system and thymic epithelial cells (VTEC2. H/S).

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

EDP tripeptide described within thymalin-related research.

What it is researched for

Experimental thymic and immune regulation through proposed lymphocyte-proliferation and gene-regulatory effects.

Research observation window

Not reported in the reviewed compound-specific evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

No sourced lyophilized-vial injectable protocol is listed for this profile.

Safety context

Reported side effects

Generally well-tolerated
Minimal side effects reported

Contraindications & cautions

Active autoimmune flares (consult physician)
Known hypersensitivity
Pregnancy or breastfeeding

Scientific references

01
The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
Scientific citationThe Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity. PMC/NCBI (2021).
02
Crystagen in Elderly Patients with Impaired Immunity
Scientific citationCrystagen in Elderly Patients with Impaired Immunity. Advances in Gerontology (2018).
03
Peptide Bioregulators in Athletes
Scientific citationPeptide Bioregulators in Athletes. Bulletin of Experimental Biology and Medicine (2019).
04
EDP Peptide Effects on Lymphocyte Proliferation
Scientific citationEDP Peptide Effects on Lymphocyte Proliferation. Cell Technologies in Biology and Medicine (2017).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

Related research profiles

Longevity