Moderate ResearchCognitiveLongevity

Cortagen

AEDP

AEDP | Brain Cortex Bioregulator Peptide

Half-life

Minutes (short peptide); effects persist via epigenetic changes

Chain length

4 amino acids

Reference frequency

Once daily for 10-20 consecutive days

Research overview

DoseGear research brief

Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.

Mechanism of action

Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

AEDP tetrapeptide attributed to St. Petersburg and Khavinson research.

What it is researched for

Experimental nervous-system injury and cellular regulation involving inflammatory, oxidative-stress, and gene-expression pathways.

Research observation window

Not reported in the reviewed compound-specific evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research context	Amount	Frequency	Route
Chart reference	1 mg	Daily · See source guide	Injectable · 20 mg lyophilized vial + 3 mL BAC Water

Reference cycle

10-20 days per cycle

Reference storage

Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

Safety context

Reported side effects

Generally well-tolerated
Minimal side effects reported

Contraindications & cautions

Active neurological emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding

Scientific references

01
Effect of Cortagen on Gene Expression in Mouse Heart
Scientific citationEffect of Cortagen on Gene Expression in Mouse Heart. Neuroendocrinology Letters (2004).
02
Delayed Effect of Cortagen on Restoration of Injured Nerve Function
Scientific citationDelayed Effect of Cortagen on Restoration of Injured Nerve Function. Doklady Biological Sciences (2002).
03
Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve
Scientific citationEffect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve. Bulletin of Experimental Biology and Medicine (2000).
04
Khavinson Peptide Bioregulators
Scientific citationKhavinson Peptide Bioregulators. Advances in Gerontology (2020).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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