Acadesine
5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator
DoseGear research brief
AICAR is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. Originally studied for cardiac ischemia protection, it gained attention as an 'exercise mimetic' due to its metabolic effects.
Once inside cells, AICAR is phosphorylated to ZMP, which mimics AMP and activates AMPK. This triggers metabolic pathways typically activated during exercise: increased glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
Compound background
Study windows describe what researchers measured, not when an individual should expect a result.
Synthetic nucleoside analog investigated in ischemia and metabolic research; it is not a peptide.
Energy metabolism, glucose handling, and exercise-related pathways through intracellular ZMP and AMPK-associated signaling.
Not reported in the reviewed compound-specific evidence.
Reference data
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Standard Protocol | 1-3mg | Daily | SubQ |
| Gradual Introduction | 1mg → 2mg → 3mg | Daily, titrating over 4 weeks | SubQ |
| Advanced Protocol | 3-5mg | Daily for 8-12 weeks | SubQ |
Reference cycle
8-12 weeks
Reference storage
Lyophilized: -20°C; Reconstituted: 2-8°C for 4 weeks
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
AICAR Mouse Endurance Study
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.
