DoseGear research brief
Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement. Benefits traumatic brain injury recovery and age-related cognitive decline with excellent safety profile.
DG Peptide Protocols
Well StudiedCognitiveSleep
Pinealon
EDR
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Research overview
Mechanism of action
Penetrates nuclear membranes to directly interact with DNA, modulates gene expression via histone H1. 3 binding and MAPK/ERK pathway activation.
Compound background
Development & research timeline
Study windows describe what researchers measured, not when an individual should expect a result.
Origin & development
Synthetic EDR tripeptide associated with Khavinson research.
What it is researched for
Experimental neuronal protection and cognition involving oxidative-stress, apoptosis, and gene-regulatory effects.
Research observation window
The source cites 14-day diabetic-rat and 28-day intraperitoneal 5xFAD-mouse experiments; a human response window is not established.
Reference data
Lyophilized vial injectable protocols
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Neuroprotection | 5mg daily | Once daily | SubQ |
| Cognitive Enhancement | 100-300mcg | Daily or every other day | SubQ |
| Anti-aging | 5mg | 20 days, 2-3x yearly | SubQ |
Reference cycle
20 days per cycle
Reference storage
Refrigerate at 2-8°C, use within 30 days after reconstitution
Safety context
Reported side effects
- Minimal injection site reactions
- Mild gastrointestinal adjustment
- Occasional headache
- Fatigue
Contraindications & cautions
- Pregnancy
- Lactation
Scientific references
- 01
Human Clinical Trial - Post-Traumatic Cerebrasthenia
Scientific citationHuman Clinical Trial - Post-Traumatic Cerebrasthenia. (2015). - 02
Aging Study - Polymorbidity Patients
Scientific citationAging Study - Polymorbidity Patients. (2015). - 03
Diabetic Rat Model - Spatial Learning
Scientific citationDiabetic Rat Model - Spatial Learning. (2020). - 04
5xFAD Alzheimer's Mouse Model
Scientific citation5xFAD Alzheimer's Mouse Model. (2021).
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.