DoseGear research brief
Modified IGF-1 variant with PEG attachment extending half-life from minutes to hours. Activates muscle satellite cells following mechanical stress or injury.
DG Peptide Protocols
Limited ResearchGrowth HormoneHealing & Recovery
PEG-MGF
Pegylated MGF
Pegylated Mechano Growth Factor | IGF-1 Splice Variant
Research overview
Mechanism of action
Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. E-peptide domain exhibits distinct activity from mature IGF-1.
Compound background
Development & research timeline
Study windows describe what researchers measured, not when an individual should expect a result.
Origin & development
PEG-modified synthetic MGF-related product.
What it is researched for
Proposed muscle-repair and anabolic research involving prolonged exposure and MGF-related repair signaling.
Research observation window
Not reported in the reviewed compound-specific evidence.
Reference data
Lyophilized vial injectable protocols
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| General Recovery | 200mcg | 2-3x weekly | SubQ or IM |
| Targeted Muscle Recovery | 200-400mcg | Post-workout, 2-3x weekly | IM bilateral near target muscle |
| Injury Recovery | 200-400mcg | 2-3x weekly | IM near injury site |
| Conservative Protocol | 100-200mcg | 2x weekly | SubQ |
Reference cycle
4-8 weeks
Reference storage
Refrigerate at 2-8°C; protect from light
Safety context
Reported side effects
- Injection site soreness
- Mild fatigue
Contraindications & cautions
- Any history of cancer or neoplastic disease
- Pregnancy or breastfeeding
- Uncontrolled diabetes or severe hyperglycemia
Scientific references
- 01
MGF-E Peptide Human Muscle Cell Study
Scientific citationMGF-E Peptide Human Muscle Cell Study. (2011). - 02
MGF Inflammatory Response Study
Scientific citationMGF Inflammatory Response Study. (2018). - 03
Mechano-Growth Factor Minireview
Scientific citationMechano-Growth Factor Minireview. (2010).
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.