DG Peptide Protocols
FDA ApprovedCognitive

Oxytocin

Pitocin

Neurohypophysial Peptide | Social Bonding & Reproductive Hormone

Half-life
3-6 minutes
Chain length
9 amino acids
Reference frequency
As needed for social/sexual support, or 1-2x daily for anxiety/PTSD protocols; max 1 dose per 24hr for sexual function

Research overview

DoseGear research brief

Nine-amino-acid peptide hormone produced in hypothalamus, released by posterior pituitary. Functions in social bonding, trust, empathy, reproduction, childbirth, lactation. FDA-approved synthetically for labor induction and postpartum hemorrhage.

Mechanism of action

Binds oxytocin receptors on uterine smooth muscle, triggering calcium influx and myometrial contractions. Stimulates prostaglandin release. In CNS, modulates GABAergic, serotonergic, dopaminergic neurotransmission; reduces cortisol and HPA axis activity.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Endogenous hypothalamic nonapeptide with synthetic pharmaceutical forms.

What it is researched for

Established obstetric use and experimental social-behavioral and metabolic applications through oxytocin-receptor agonism.

Research observation window

Not reported for an attributable injectable-vial response window in the reviewed evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research contextAmountFrequencyRoute
Labor Induction0.5-2 mU/min initial, titrate to 1-2 mU/min every 30-60 minContinuous IV infusionIV (diluted)
Postpartum Hemorrhage Prevention10 units IM or 10-40 units in IV solutionSingle dose after placental deliveryIM or IV infusion

Reference cycle

As needed for research applications; 4-12 weeks for anxiety/autism protocols

Reference storage

Refrigerate at 2-8°C; protect from light

Safety context

Reported side effects

  • Mild headache
  • Nasal irritation (intranasal)
  • Nausea or vomiting
  • Transient blood pressure changes

Contraindications & cautions

  • Certain obstetric conditions (see prescribing info)
  • Pregnancy (without medical supervision)
  • Active sinus infection (intranasal)
  • Severe hyponatremia

Scientific references

  1. 01

    Intranasal Oxytocin in Autism Spectrum Disorder

    Scientific citationIntranasal Oxytocin in Autism Spectrum Disorder. (2021).
  2. 02

    Oxytocin Augmented Prolonged Exposure Therapy for PTSD

    Scientific citationOxytocin Augmented Prolonged Exposure Therapy for PTSD. (2019).
  3. 03

    Intranasal Oxytocin for Obesity

    Scientific citationIntranasal Oxytocin for Obesity. (2024).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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