DG Peptide Protocols
Well StudiedHealing & RecoveryImmune

LL-37

Human Cathelicidin

Human Cathelicidin | Antimicrobial Peptide

Half-life
Short (rapid proteolytic degradation)
Chain length
37 amino acids
Reference frequency
Topical: Daily to twice weekly on wounds. Injectable: Once daily subcutaneous

Research overview

DoseGear research brief

LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide derived from hCAP18 that exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi while modulating immune responses.

Mechanism of action

Provides direct antimicrobial activity through membrane disruption, promotes wound healing by enhancing keratinocyte migration and angiogenesis, and modulates immune responses without systemic exposure when used topically.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Human cathelicidin-derived antimicrobial peptide.

What it is researched for

Host defense, inflammation, and wound repair through membrane interactions and context-dependent immune-cell signaling.

Research observation window

Not reported in the reviewed compound-specific evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research contextAmountFrequencyRoute
Chart reference50 mcgDaily · See source guideInjectable · 5 mg lyophilized vial + 3 mL BAC Water

Reference cycle

2-8 weeks depending on wound healing progress

Reference storage

Lyophilized: 2-8°C; Reconstituted: 2-8°C, maintain sterility

Safety context

Reported side effects

  • Generally well-tolerated
  • Mild injection site reactions (injectable)
  • Local irritation at application site (topical)

Contraindications & cautions

  • Pre-existing hypersensitivity to peptides
  • Compromised immune status (relative contraindication)
  • Non-sterile wound environments

Scientific references

  1. 01

    Venous Leg Ulcer Trial - Grönberg et al.

    Scientific citationVenous Leg Ulcer Trial - Grönberg et al.. Wound Repair and Regeneration (2014).
  2. 02

    Melanoma Phase I Trial

    Scientific citationMelanoma Phase I Trial. (2015).
  3. 03

    MRSA Biofilm Study - Noore et al.

    Scientific citationMRSA Biofilm Study - Noore et al.. PLOS ONE (2019).
  4. 04

    Structural Analysis - Wang et al.

    Scientific citationStructural Analysis - Wang et al.. Journal of Biological Chemistry (2008).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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