Somatropin
Human Growth Hormone | Somatropin
DoseGear research brief
Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions. It provides both direct and indirect (IGF-1 mediated) anabolic effects.
Binds to GH receptors on target tissues, triggering JAK2-STAT5 signaling pathway. Direct effects include lipolysis, protein synthesis, and metabolic regulation. Indirect effects via IGF-1 promote growth and anabolism. Half-life ~3 hours subcutaneously.
Compound background
Study windows describe what researchers measured, not when an individual should expect a result.
Endogenous 191-amino-acid growth hormone; its recombinant form is somatropin.
Growth-hormone deficiency and related growth and metabolic research through GH-receptor/JAK2–STAT and IGF-I signaling.
A cited KIMS observational cohort had mean 5.3-year follow-up; this is not a time-to-benefit estimate.
Reference data
Not personalized dosing instructions
Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.
| Research context | Amount | Frequency | Route |
|---|---|---|---|
| Medical GHD (Starting) | 0.15-0.3mg/day (0.5-1 IU) | Once daily | SubQ |
| Medical GHD (Maintenance) | 0.4-0.8mg/day (1.2-2.4 IU) | Once daily | SubQ |
| Anti-Aging/Wellness | 1-2 IU/day (0.33-0.67mg) | Once daily | SubQ |
| Body Recomposition | 2-4 IU/day (0.67-1.33mg) | Once or twice daily | SubQ |
| Performance (Higher Risk) | 4-8 IU/day (1.33-2.67mg) | Split twice daily | SubQ |
Reference cycle
3-6+ months or ongoing for medical GHD
Reference storage
Lyophilized: Room temperature; Reconstituted: 2-8°C, use within 14-28 days
Long-term Safety of Growth Hormone in Adults With Growth Hormone Deficiency: Overview of 15,809 GH-Treated Patients
Efficacy and Safety of Growth Hormone Treatment in Adults with Growth Hormone Deficiency: A Systematic Review of Studies on Morbidity
Cardiovascular Risk in Growth Hormone Deficiency: Beneficial Effects of Growth Hormone Replacement Therapy
Unmasking of Central Hypothyroidism Following Growth Hormone Replacement in Adult Hypopituitary Patients
This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.
