DG Peptide Protocols
Well StudiedHealing & RecoverySkin & Hair

GHK-Cu

Copper Peptide | Skin Regeneration & Anti-Aging Compound

Half-life
0.5-2 hours
Chain length
3 amino acids
Reference frequency
1-2x daily

Research overview

DoseGear research brief

Naturally occurring copper tripeptide found in human plasma, saliva, and urine. GHK-Cu affects 31. 2% of human genes and declines significantly with age—from ~200 ng/ml at age 20 to ~80 ng/ml at age 60. Known for exceptional skin regeneration, wound healing, and anti-aging properties.

Mechanism of action

Penetrates skin layers, activates fibroblasts, stimulates collagen and elastin synthesis, promotes angiogenesis, and modulates inflammatory responses. The copper ion is essential for enzyme cofactor activity in tissue repair processes.

Compound background

Development & research timeline

Study windows describe what researchers measured, not when an individual should expect a result.

Origin & development

Naturally occurring GHK tripeptide complexed with copper.

What it is researched for

Skin, wound-healing, and extracellular-matrix research involving fibroblast, remodeling, and inflammatory signaling.

Research observation window

Not reported in the reviewed compound-specific evidence.

Reference data

Lyophilized vial injectable protocols

Not personalized dosing instructions

Only injectable vial references are shown. Nasal, topical, and unsupported non-vial schedules are excluded.

Research contextAmountFrequencyRoute
Chart reference1 mgFive days per week · See source guideInjectable · 50 mg lyophilized vial + 3 mL BAC Water

Reference cycle

8-16 weeks

Reference storage

Room temperature (topical) or 2-8°C (injectable)

Safety context

Reported side effects

  • Mild skin irritation initially (usually resolves)
  • Increased photosensitivity

Contraindications & cautions

  • Known copper sensitivity or Wilson's disease
  • Active skin infections at application site
  • Pregnancy or breastfeeding (injectable)

Scientific references

  1. 01

    Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

    Scientific citationRegenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences (2018).
  2. 02

    GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

    Scientific citationGHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International (2015).
  3. 03

    The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health

    Scientific citationThe human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative Medicine and Cellular Longevity (2012).
  4. 04

    Tripeptides GHK and GHK-Cu-modified silver nanoparticles for enhanced antibacterial and wound healing activities

    Scientific citationTripeptides GHK and GHK-Cu-modified silver nanoparticles for enhanced antibacterial and wound healing activities. Colloids and Surfaces B: Biointerfaces (2024).

This DoseGear profile combines published scientific literature with lyophilized-vial protocol references. Citations are provided for independent review.

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